Alzheimer's Tennessee, Inc. – Support, Education and Research for Alzheimer's Disease and Related Dementias
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Hormone therapy and Alzheimer's disease

For women, a drop in hormones during midlife may have some influence on developing dementia or Alzheimer’s disease. Also, general brain volume gradually declines with advancing age, but the decline is faster in people who experience more cognitive decline.

“So, preserving brain volume during middle age, particularly in women as they transition into menopause, may protect against dementia and delay the occurrence of Alzheimer’s symptoms,” says Dr. Kejal Kantarci, a radiologist in the Division of Neuroradiology at Mayo Clinic. She studies how the brain changes with aging and how brain diseases affect those changes. Dr. Kantarci says imaging can provide a window into the changes, decades before someone begins to show clinical symptoms of Alzheimer’s or dementia.

She says, “With hormone therapy in our study, we observed that the women who took the hormone therapy had a slower rate of brain changes, whereas women who did not take hormone therapy had a faster rate of brain changes; therefore, our conclusion was that perhaps hormone therapy given in the middle ages may slow brain volume changes and perhaps help prevent dementia in the future.”

Dr. Kantarci adds,”Certainly more time and research are needed before we know whether hormone therapy regimens are preventing dementia in women. In the meantime, imaging techniques can be used to determine whether women using hormone therapies during the menopausal transition are receiving any brain benefits.

 

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