Alzheimer’s Tennessee, Inc. – Support, Education and Research for Alzheimer’s Disease and Related Dementias

Research News

Alzheimer's brain damage halved with gene-targeting compound

The APOE gene, responsible for encoding a protein called apolipoprotein E, is known to dramatically raise the risk of Alzheimer's.


Also, studies show that people who have both copies of the gene have a 12-fold higher risk of developing Alzheimer's disease.


Recent research has focused on understanding the role of APOE in Alzheimer's formation. For instance, Medical News Today recently reported on a study led by Dr. David Holtzman, head of the Department of Neurology at the Washington University School of Medicine in St. Louis, MO.


In that very study, Dr. Holtzman uncovered the mechanism by which the APOE protein amplifies Alzheimer's disease-related brain damage in mice, and he suggested that future research should focus on targeting the protein to nip the neurodegenerative process in the bud.


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